What is GLP-3 RT?

An investigational triple agonist peptide studied against glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, and glucagon receptors in metabolic research.

Research use only. Not for human or veterinary use.

GLP-3 RT

Reference profile — not currently in the Vybe catalog

Overview

Retatrutide is a synthetic peptide ligand engineered to engage three incretin-related receptors. Peer-reviewed clinical and preclinical papers describe receptor potency, pharmacokinetics, and metabolic endpoints in controlled trials. Those publications belong to the original authors and journals. Vybe does not market retatrutide as a medicine; listed vials are research materials with lot documentation.

Research areas

Framed as published laboratory and clinical literature. Not treatment guidance.

Incretin receptor pharmacology

Biochemical assays characterize binding and cAMP responses at GIP, GLP-1, and glucagon receptors, which is the basis for calling the molecule a triple agonist.

Controlled metabolic trials

Phase 2 literature reports body-composition and glycemic measures in adult participants under medical protocols. That clinical context is not a use guide for catalog material and must not be copied as a personal regimen.

Published research

Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
PMID 37366315 · DOI 10.1056/NEJMoa2301972
Open source
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss
Cell Metabolism · 2022
PMID 35675825 · DOI 10.1016/j.cmet.2022.05.011
Open source

Storage & handling

Keep lyophilized peptide cold, dry, and away from light per the lot certificate. This is laboratory storage guidance only.

Frequently asked questions

What is retatrutide?

A synthetic triple-receptor agonist peptide (LY3437943) described in metabolic research literature. Vybe supplies it as a research reagent only.

What is its CAS number?

2381089-83-2.

Is this sold for human use?

No. Not for human or veterinary use. Published trial protocols are not instructions for this catalog item.

Key facts

Full name: Retatrutide (LY3437943)
Common name: GLP-3 RT
CAS number: 2381089-83-2
Molecular formula: C223H343N46O70
Molecular weight: 4845.44
Research category: Metabolic
Storage: Keep lyophilized peptide cold, dry, and away from light per the lot certificate. This is laboratory storage guidance only.